Protein Details: Potassium voltage-gated channel subfamily H member 2

Protein ID

ICDB_Pro_1644

Protein Name

Potassium voltage-gated channel subfamily H member 2

Gene Name

KCNH2; CERG; ERG

Organism

Canis lupus familiaris (Dog) (Canis familiaris)

Length

1158 amino acids

AlphaFoldDB

AF-Q9TSZ3-F1-model_v4.pdb

Function

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity)

Sequence

MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPTHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTTRESSARPGGVGSAGAPGAVVVDVDLSPAVPSRESLALDEVTAMDNHVAGLGPMEEQRALVGSSSPPAGAPEPLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGLPPPPRHASTGAMHPLRGGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPAPDCGYACQPLAVVDFIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSAELEGGFNRQRKRKLSFRRRTDRDPEQPGEVSALGPGRAGAGPSGRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLTEDGEKSSDTCNPLSGAFSGVSNIFSFWGDSRGHQYQELPRCPAPTPSLLNIPLSSPCRRPRGDVEGRLDALQRQLNRLETRLSADMATVLQLLQRQMTLIPPAYSAVTTPGPGPTSTSSLLPVSPIPTLTLDSLSQVSQFMAFEELPPGAPELPQDGPPRRLSLPGQLGALTSQPLHRHGSDPGS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

741..858

Disease

Location

Highly expressed in left and right atria of the heart; in cortex and hippocampus; detected at intermediate levels in left and right ventricle; Purkinje fibers; cerebellum; thalamus and basal ganglia; detected at low levels in liver; spleen and kidney.

DOI ID

10.1007/s004240100524; 10.1161/01.res.80.2.261; 10.1161/01.res.84.7.776

RefSeq

NP_001003145.1